Copper brain homeostasis: Role of amyloid precursor protein and prion protein
نویسندگان
چکیده
منابع مشابه
Copper promotes the trafficking of the amyloid precursor protein.
Accumulation of the amyloid β peptide in the cortical and hippocampal regions of the brain is a major pathological feature of Alzheimer disease. Amyloid β peptide is generated from the sequential protease cleavage of the amyloid precursor protein (APP). We reported previously that copper increases the level of APP at the cell surface. Here we report that copper, but not iron or zinc, promotes A...
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Authors: Karla M. Acevedo, Ya Hui Hung, , Andrew H. Dalziel , Qiao-Xin Li , Katrina Laughton , Krutika Wikhe, Alan Rembach , Blaine Roberts , Colin L. Masters, , Ashley I. Bush 4 and James Camakaris. From Department of Genetics, Department of Pathology, Centre for Neuroscience, Mental Health Research Institute, The University of Melbourne, VIC, Australia; CSIRO Molecular and Health Technologies...
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Amyloidprecursor protein (APP), a type I membrane protein, is physiologically processed by or -secretases that cleave APP N-terminal to the transmembrane region. Extracellular -cleavage of APP generates a large secreted N-terminal fragment, and a smaller cellular C-terminal fragment. Subsequent -secretase cleavage in the transmembrane region of the C-terminal fragment induces secretion of small...
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ژورنال
عنوان ژورنال: IUBMB Life (International Union of Biochemistry and Molecular Biology: Life)
سال: 2005
ISSN: 1521-6543,1521-6551
DOI: 10.1080/15216540500264620